For published plasmids, antibodies and mouse models (which we are absolutely happy to share), please send all requests to Dr. Ling Qi (lingq@med.umich.edu).

2023

• Lin, L.L., Wang, H.H., Wei, X., Pederson, B., Torres, M., Li, Z.J., Liu, X., Mao, H., Zhen, Z., Sun, S. and Qi, L.  SEL1L-HRD1 interaction is a prerequisites step in the formation of a functional HRD1 ERAD complex. BioRxiv. 2023. under review in Nat Comm

• Wei, X., Lu, Y., Lin, L.L., Zhang, C., Chen, X., Wang, S., Wu, S.A., Sun, S. and Qi, L.  Proteomic screens of SEL1L-HRD1 ER-associated degradation substrates reveal its vital importance in the biogenesis of glycosylphosphatidylinositol-anchored proteins. under revision in Nat Comm.

• Abdon, B., Liang, Y., Torres, M., Kersten, S., and Qi, L. 2023. Systemic Regulation of Growth and Energy Metabolism by Myocyte-specific SEL1L-HRD1 ER-associated Degradation. JCI Insight. (accepted)

• Zhang, X., Young, C., Liao, X., Refetoff, S., Torres, M., Tomer, Y., Stefan-Lifshitz., M., Zhang, H., Larkin, D., Fang, D., Qi, L. and Arvan, P. 2023. Perturbation of Endoplasmic Reticulum proteostasis triggers tissue injury in the thyroid gland. JCI Insight 8 (12): e169937. PMID: 37345654

• Zhuang, Y., Li, Z., Xiong, S., Sun, C., Li, B., Wu, S.A., Lyu, J., Shi, X., Yang, L., Chen, Y., Bao, Z., Li, X., Sun, C., Chen, Y., Deng, H., Li, T., Wu, Q., Qi, L., Huang, Y., Yang, X., and Lin, Y. 2023. Circadian clocks are modulated by compartmentalized oscillating translation. Cell. June 20; S0092-8674(23)00599-8

• Wu., S.A., Chen, X., Wei, X., Zhang, X., Wang, S., Chen, X., Torres, M., Lu, Y., Lin, L.L., Wang, H., Hunter, A., Fang, D., Sun, S., Ivanova, M., Lin, Y., and Qi, L. 2023. The mechanisms to dispose of misfolded proteins in the endoplasmic reticulum of adipocytes. Nat Comm. 14(1):3132. PMID: 37253728

• Liang T, Smith CE, Hu Y, Zhang H, Zhang C, Xu Q, Lu Y, Qi L, Hu JC, and Simmer JP. 2023. Dentin defects caused by a Dspp(-1) frameshift mutation are associated with the activation of autophagy. Sci Rep. 13(1):6393. PMID: 37076504

• Xu, X., Arunagiri, A., Alam, M., Haataja, L., Evans, C.R., Zhao, I., Castro-Gutierrez, R., Russ, H.A., Demangel, C., Qi, L., Tsai, B., Liu, M., Arvan, P. Nutrient-dependent regulation of β-cell proinsulin content. 2023. J Biol Chem. May 18: 104836 PMID: 37209827

• Ji, Y., Luo, Y., Wu, Y., Sun, Y., Zhao, L., Xue, Z., Sun, M., Wei, X., He, Z., Wu, A.S., Lin, L.L., Lu, Y., Chang, L., Chen, F., Chen, S., Qian, W., Xu, X., Chen, S., Pan, D., Zhou, Z., Xia, S., Hu, C.C.A., Liang, T., and Qi, L. SEL1L-HRD1 endoplasmic reticulum-associated degradation controls STING mediated innate immunity by limiting the size of activable STING pool. Nat Cell Biol. May 4th. PMID: 37142791  (News and Views)  (Research Briefing)

2022

• Shrestha, N., Torres, M., Knupp, J., Chen, Y.J., Lu, Y., Haataja, L., Zhang, J., Tsai, B., Arvan, P., and Qi, L. 2022. Integration of ER quality control mechanisms defines β-cell function and ER architecture. J Clin Invest. PMID: 36346671 (cover below) 

• Bhattacharya, A., Wei, J., Song, W., Gao, B., Tian, C., Wu, S.A., Wang, J., Chen, L., Fang, D., and Qi, L.  2022. SEL1L-HRD1 ER-associated degradation suppresses hepatocyte hyperproliferation and liver cancer. iScience. 25(10): 105183. PMID: 36238898

• Xu, X., Arunagiri, A., Haataja, L., Alam, M., Ji, S., Qi, L., Tsai, B., Liu, M., Arvan, P. Proteasomal degradation of WT proinsulin in pancreatic β cells. 2022. J Biol Chem. 298 (10): 102406 PMID: 35988641

• Yao, X., Wu, Y., Xiao, T., Zhao, C., Gao, F., Liu, S., Tao, Z., Jiang, Y., Chen, S., Ye, J., Yao, X., Wu, Y., Xiao, T., Zhao, C., Gao, F., Liu, S., Tao, Z., Jiang, Y., Chen, S., Ye, J., Chen, H., Long, Q., Wang, H., Zhou, X., Shao Q., Qi, L., and Xia, S. 2022. T-cell-specific Sel1L deletion exacerbates EAE by promoting Th1/Th17-cell differentiation. Mol Immunol. 149: 13-26  PMID: 35696849

2021

• Liu, X., Yu, J., Xu, L., Umphred-Wilson, K., Peng, F., Ding, Y., Barton, B.M., Lv, X., Zhao, M.Y., Sun S, Hong, Y., Qi, L., Adoro, S., and Chen, X. 2021.  Notch-induced endoplasmic reticulum-associated degradation governs mouse thymocyte beta- selection. eLife. 10: 10.7554/eLife.69975  PMID: 34240701.

•  El Manaa W, Duplan E, Goiran T, Lauritzen I, Vaillant Beuchot L, Lacas-Gervais S, Morais VA, You H, Qi L, Salazar M, Ozcan U, Chami M, Checler F, Alves da Costa C. Transcription- and phosphorylation-dependent control of a functional interplay between XBP1s and PINK1 governs mitophagy and potentially impacts Parkinson disease pathophysiology. Autophagy. 2021 May 24:1-23. doi: 10.1080/15548627.2021.1917129. PMID: 34030589

• Yoshida, S., Wei, X., Zhang, G.m O’Connor, C., Torres, M., Lin, L., Zhou, Z., Xu, Xl., Xiong, Y., Menon, R., Ottto, E.m Tang, C.H.A., Veram, R., Mori, H., Zhang, Y., Hu, A.C.A., Liu, M., Garg, P., Bitzer, M., and Qi, L.  2021. Endoplasmic reticulum-associated degradation is required for nephrin maturation and kidney glomerular filtration function. J Clin Invest. Feb 16: 143988. (Cover)

• Liu, M., Huang, Y., Xu, X., Li, X., Alam, M., Arunagiri., A., Haataja, L., Ding, L., Wang, S., Itkin-Ansari, P., Kaufman, R., Tsai, B., Qi, L., and Arvan, P. 2021. Normal and defective pathways in biogenesis and maintenance of the insulin storage pool. J Clin Invest. 131 (2): e142240.

• Wu, S.C., Kersten S., and Qi, L. 2021. Lipoprotein lipase and its regulators: an unfolding story. Trends Endocrinol Metab. 32 (1): 48-61. PMID: 33277156.

2020

• Liu, L., Inoki, A., Fan, K., Mao, F., Shi, G., Jin, X., Zhao, M., Ney, G., Sun, S., Dou, Y., Inoki, K., Qi, L., and Li, Q., 2020.  ER-associated degradation preserves hematopoietic stem cell quiescence and self-renewal by restricting mTOR activity. Blood. 136 (26): 2975-86.  PMID: 33153081

• Xu, L., Liu, X., Peng, F., Zhang, W., Zheng, L., Ding, Y., Gu, T., Lv, K., Wang, J., Ortinau, L.C., Hu, T., Shi, C., Shi, G., Shang, G., Sun, S., Iwawaki, T., Ji, Y., Li, W., Rosen, J.M., Zhang, X.H.F., Park, D., Adoro, S., Catic, A., Wei, T., Qi, L., Nakada, D., and Chen, X. 2020.  Protein quality control through ERAD maintains hematopoietic stem cell identity and niche interactions. Nat Cell Biol. Sep 21. 22 (10): 1162-69.  PMID: 32958856

• Shrestha, N., Reinert, R.B., and Qi, L. 2020. Endoplasmic reticulum protein quality control in β cells. Seminars in Cell & Dev Biol.  103: 59-67  PMID: 32402517

• Shrestha, N., Liu, T., Ji, Y., Reinert, R.B., Torres, M., Li, X., Zhang, M., Tang, C.A., Hu, C.A., Liu, C., Naji, A., Liu, M., Lin, J., Kersten, S., Arvan, P. and Qi, L. 2020. Sel1L-Hrd1 ER-associated degradation maintains β cell identity via TGFβ signaling. J Clin Invest.  130 (7): 3499-3510  PMID: 32182217

• Zhou, Z., Torres, M., Sha, H., Van den Bergh, F., Halbrook, C.J., Yamada, T., Hunter, A., Taylor, A., Sanderson, T.H., Sesake, H., Lyssiotis, C.A., Wu, J., Kersten, S., Reinert, R.B., Beard, D., and Qi, L. 2020. Endoplasmic reticulum-associated degradation regulates mitochondrial dynamics in brown adipocytes. Science. 358: 54-60. PMID: 32193362 .  (free)  Full text    PDF .  (Press release ERAD in BAT)

• Zhao, X., Zhou, L., Chen, Z., Ji, Y., Peng, X., Qi, L., Li, S., and Lin, J.D. 2020 The obesity-induced adipokine sST2 exacerbates adipose Treg and ILC2 depletion and promotes insulin resistance. Science Advances. May 13. 6 (20): eaay6191.  PMID: 32426492

• Bagchi, P., Torres, M., Qi, L., and Tsai, B.  2020. Selective EMC subunits act as a molecular tethers of intracellular organelles exploited during viral entry. Nat Commun. 11: 1127    PMID: 32111841

• Young, K.Z., Lee, S.J., Zhang, X., Cartee, N.M.P., Torres, M., Keep, S.G., Gabbireddy, S.R., Fontana, J.L., Qi, L., and Wang, M.M. 2020. NOTCH3 is non-enzymatically fragmented in inherited cerebral small-vessel disease. J Bio Chem. 295: 1960-72 PMID: 31901894

2019

• Li, X., Itani, O.A., Haataja, L., Dumas, K.J., Yang, J., Cha, J., Flibotte, S., Shih, H-J., Delaney, C.E., Xu, J., Qi, L., Arvan, P., Liu, M. and Hu, P.J. 2019 Requirement for translocon-associated protein (TRAP) α in insulin biogenesis. Science Advance.  5 (12): eaax0292. PMID: 31840061

• Bhattacharya, A. and Qi, L. 2019.  ER-associated degradation in health and disease - from substrate to organism. J Cell Sci.  132 (23). pii: jcs232850. doi: 10.1242/jcs.232850 PMID: 31792042

• Sheng, H., Ji, Y., Xiong, Y., Kim, H., Zhong, X., Jin, M.G., Shah, Y.M., Omary, B.M, Liu, Y., Qi, L., and Rui, L. 2019.  Medullary thymic epithelial NF-kB-inducing kinase (NIK)/IKKα pathway shapes autoimmunity and liver and lung homeostasis in mice. Proc Natl Acad Sci U S A.   116: 19090-97. PMID: 31481626

• Xiong, X., H. Kuang, S. Ansari, T. Liu, J. Gong, S. Wang, X.Y. Zhao, Y. Ji, C. Li, L. Guo, L. Zhou, Z. Chen, P. Leon-Mimila, M.T. Chung, K. Kurabayashi, J. Opp, F. Campos-Perez, H. Villamil-Ramirez, S. Canizales-Quinteros, R. Lyons, C.N. Lumeng, B. Zhou, L. Qi, A. Huertas-Vazquez, A.J. Lusis, X.Z.S. Xu, S. Li, Y. Yu, J.Z. Li, and J.D. Lin. 2019. Landscape of Intercellular Crosstalk in Healthy and NASH Liver Revealed by Single-Cell Secretome Gene Analysis. Mol Cell. 75:644-660 e645. PMID: 31398325

• Cho, H., Stanzione, F., Oak, A., Kim, G.H., Yerneni, S., Qi, L., Sum, A.K., and Chan, C. 2019. Intrinsic Structural Features of the Human IRE1α Transmembrane Domain Sense Membrane Lipid Saturation. Cell reports 27, 307-320 e305. PMID: 30943411. 

• Ji, Y.*, Sun, S.*, Shrestha, N., Darragh, L., Shirakawa, J., Xing, Y., He, Y., Carboneau, B.A., Kim, H., Oberhozler, J., Soleimanpour, S.A., Gannon, M., Liu, C., Naji, A., Kulkarni, R., Wang, Y., Kersten, S., and Qi, L.  2019. Toll-like receptors 2 and 4 act as brakes on beta cell mass expansion in diet-induced obesity. Nat Immunol. 20, 677-686. (Cover)

2018

• Bhattacharya, A., Sun, S., Wang, H., Long, Q., Liu, M., Yin, L., Kersten, S., Zhang, K., and Qi, L. 2018. Hepatic Sel1L-Hrd1 ER-associated degradation manages FGF21 levels and systemic metabolism via CREBH. EMBO J.  Online 11/2/18; See Commentary  "Hepatic ERAD takes control of the organism".  See Editor's Choice in Science Signaling.  Recommended by F1000Prime.

•  Schultz, M.L., Krus, K.L., Kaushik, S., Dang, D., Chopra, R., Qi, L., Shakkottai, V.G., Cuervo, A.M., Lieberman, A.R. 2018. Coordinate regulation of mutant NPC1 degradation by selective ER autophagy and MARCH6-dependent ERAD. Nat Communication 9: 3671

• Hwang, J. and Qi, L. 2018. Quality control in the Endoplasmic Reticulum: Crosstalk between ERAD and UPR pathways. Trends in Biomedical Sciences. 43: 593-605  PMID: 30056836

• Urra, H., Henriquez, D.R., Canovas, J., Villarroel-Campos, D., Carreras-Sureda, A., Pulgar, E., Molina, E., Harzari, Y.M., Limia, C.M., Alvarez-Roajas, S., Figueroa, R., Vidal, R.L., Rodriguez, D.A., Rivera, C.A., Court, F., Couve, A., Qi, L., Chevet, E., Akai, R., Iwawaki, T., Concha, Ml., Glavic, A., Gozalez-Billault, C., and Hetz, C. 2018. IRE1α govens cytoskeleton remodelling and cell migration thrugh a direct interaction with filamin A. Nat Cell Biol.  20 (8): 942-53  PMID: 30013108

• Kim, G.H., Shi, G., Somlo DR, Haataja, L., Song, S., Long, Q., Nillni, E.A., Low, M.J., Arvan, P., Myers, M.G. Jr, and Qi, L. 2018. Hypothalamic ERAD regulates POMC maturation, feeding, and age-associated obesity. J Clin Invest. 128(3): 1125-1140. PMID: 29457782. See highlights in Nat Review Endocrinology.

• Arunagiri, A., Haataja, L., Cunningham, C.N., Shrestha, N., Tsai, B., Qi, L., Liu, M, and Arvan, P. 2018. Misfolded proinsulin in the endoplasmic reticulum during development of beta cell failure in diabetes. Ann NY Acad Sci.  DOI: 10.1111/nyas.13531  PMID: 29377149.

• An, D., Chiu, A., Flanders, J.A., Song, W., Shou, D., Lu, Y.C., Grunnet, L.G., Winkel, L., Ingvorsen, C., Christophersen, N.S., Fels, J.J., Sand, F.W., Ji, Y., Qi, L., Pardo, Y., Luo, D., Silberstein, M., Fan, J., and Ma, M. 2018. Designing a retrievable and scalable cell encapsulation device for potential treatment of type 1 diabetes. Proc Natl Acad Sci U S A.  115 (2): E263-72  PMID: 29279393.

2017

• Shi, G*, Somlo, D.*, Kim, G.H.*, Prescianotto-Baschong, C., Sun, S., Beuret, N., Rutishauser, J., Long, Q., Arvan, P, Spiess, M., and Qi, L. 2017. Endoplasmic reticulum-associated degradation is required for vasopressin prohormone processing and systemic water homeostasis. J Clin Invest. 127 (10): 3897-3912 (PDF). Commentary (PDF); RESEARCH HIGHLIGHT Nat Rev Nephrology; and News from UoM Press Release. 

• Ateng, A., Bhattacharya, A., Brodesser, S., Qi, L., Tan, N.S., Kersten, S. 2017 Feeding Angptl4-/- mice trans fat promotes foam cell formation in mesenteric lymph nods without leading to ascites. J Lipid Res. April 15. PMID: 28412693.

• Dijk, W., Mattijssen F., de la Rosa Rodriguez, M., Loza Valdes, A., Loft, A., Mandrup, S., Kalkhoven, E., Qi, L., Borst, J.W., Kersten, S. 2017 Hypoxia-inducible lipid droplet-associated (HILPDA) is not a direct physiological regulator of lipolysis in adipose tissue. Endocrinology. Mar 17. PMID: 28323980

• Zhu, S., Liu, H., Sha, H., Qi, L., Gao, D.S., Zhang, W. 2017. PERK and XBP1 differentially regulate CXCL10 and CCL2 production. Exp Eye Res.155: 1-14. [Pubmed]

• Qi, L, Tsai, B. and Arvan, P. 2017. New insights into the physiological role of endoplasmic reticulum-associated degradation.  Trends in Cell Biology. Online Jan 25th. [Pubmed]

2016

• Ji, Y.*, Kim, H.*, Yang, L., Sha, H., Roma, C.A., Long, Q., and Qi, L.  2016. The Sel1L-Hrd1 endoplasmic reticulum-associated degradation complex manages a key checkpoint in B cell development.  Cell Reports. Sept 6. 16 (10): 2630-40 PMID 27568564  [Pubmed] 

• Sun, S. (co-corresponding), Louri, R., Cohen, S.B., Ji, Y., Goodrich, J.K., Poole, A.C., Ley, R.E., Denkers, E.Y., Mcguckin, M.A., Long, Q., Duhamel, G.E., Simpson, K.W., and Qi, L. 2016. Epithelial Sel1L is required for the maintenance of intestinal homeostasis. Mol Biol Cell. Feb 1; 27(3):483-90   PMID 26631554 [Pubmed]      

2015

• Sun, S.*, Shi, G.*, Sha, H., Ji, Y., Han, X., Shu, X., Ma, H., Inoue, T., Gao, B., Kim, H., Bu, P., Guber, R., Shen, X., Lee, A.H., Iwawaki, T., Paton, A.W., Paton, J.C., Fang, D., Tsai, B., Yates, J.R., 3rd, Wu, H., Kersten, S., Long, Q., Duhamel, G.E., Simpson, K.W., and Qi, L. 2015. IRE1α is an endogenous substrate of endoplasmic reticulum-associated degradation. Nat Cell Biol. 17(12): 1546-55  PMID: 26551274 [Pubmed] 

• Xia, S., Li, X., Cheng, L., Han, M., Zhang, M., Shao, Q., Xu, H., and Qi, L. 2015. Fish oil rich diet promotes hematopoiesis and alters hematopoietic niche. Endocrinology.  June 10. [Epub ahead of print]   PMID: 26061726 [Pubmed]. 

• Ma, H., Dang, Y., Wu, Y., Zhang, J., Abraham, S., Choi, J.G., Shi, G., Qi, L. Shankar, P., Manjunath, N., and Wu, H. 2015. A CRISPR-Cas9-based screen for human genes essential for West Nile virus-induced cell death. Cell Reports. 12: 673-83 [Pubmed] 

• Liu, X., Sadhukhan, S., Sun, S., Wagner, G.R., Hirschey, M.D., Qi, L. , Lin, H., Locasale, J.W. 2015. High resolution metabolomics with acyl-CoA profiling reveals widespread remodeling in response to diet. Mol Cell Proteomics. Mar 20. [Epub ahead of print] PMID: 25795660 [Pubmed]. 

• Kim, H.*, Bhattacharya, A.*, and Qi, L. 2015. Endoplasmic reticulum quality control in cancer: friend or foe. Seminars in Cancer Biology.  Mar 18. [Epub ahead of print]  PMID: 25794824 [Pubmed].

2014

• Sha, H., Sun, S., Francisco, A., Ehrhardt, N., Xue, Z., Guber, R., Panhwar, M.S., Liu, L., Brenna, T.J., Hang, S., Xue, B., Kersten, S., Bendadoun, A., Peterfy, M., Long, Q. and Qi, L. 2014. The ER-associated degradation adaptor protein Sel1L regulates LPL secretion and lipid metabolism. Cell Metabolism. 20: 458-470 [Pubmed].

• An, D., Ji, Y., Chiu, A., Lu, Y.C., Song, W., Zhai, L., Qi, L., Luo, D., Ma, M. 2014. Developing robust, hydrogel-based, nonfiber-enabled encapsulation devices (NEEDs) for cell therapies. Biomaterials. Oct 23; 37C: 40-48. [Pubmed].

• Mattijssen F, Georgiadi A, Andasarie T, Szalowska E, Zota A, Krones-Herzig A, Heier C, Ratman D, De Bosscher K, Qi L, Zechner R, Herzig S, Kersten S. 2014. Hypoxia inducible lipid droplet associated (HILPDA) is a novel peroxisome proliferator-activated receptor (PPAR) target involved in hepatic triglyceride secretion. J Biol Chem. May 29. pii: jbc.M114.570044. [PubMed]

• Ji, Y.*, Sun, S.*, Goodrich, J.K., Poole, A.C., Kim, H., Ley, R.E., Duhamel, G. and Qi, L. 2014. Diet-induced alterations in gut microflora contribute to lethal pulmonary damage in TLR2/TLR4 deficient mice. Cell Reports. Jul 10;8(1):137-49

• An, D., Lessard, S.J., Toyoda, T., Lee, M.Y., Koh, H.J., Qi, L., Hirshman, M.F. and Goodyear, L.J. 2014. Overexpression of TRB3 in muscle alters muscle fiber type and improves exercise capacity in mice. American Journal of Physiology Regulatory, Integrative and Comparative Physiology. April 16. [Epub ahead of print] PMID: 24740654 [PubMed]

• Xia, S, Li, X., Cheng, L., Han, M., Zhang, M., Liu, X., Xu, H., Zhang, M., Shao, Q., and Qi, L. 2014. Chronic Intake of High Fish Oil Diet Induces Myeloid-Derived Suppressor Cells to Promote Tumor Growth. Cancer Immunol Immunother. Apr 2. PMID: 24691944 [PubMed]

• Sun, S.*, Shi, G.*, Han, X., Francisco, A.B., Ji, Y., Mendoca, N., Liu, X., Locasale, J., Duhamel, G., Kersten, S., Yates, J., Long, Q. and Qi, L. 2014. Sel1L is Indispensable for Mammalian ERAD, ER Homeostasis and Survival. Proc. Natl. Acad. Sci. USA. 111: E582-91 [PubMed]

• Qi, L. 2014. Tipping the balance in metabolic regulation: regulating regulatory T cells by co-stimulation. Diabetes. 63: 1179-81. [PubMed]

2013

• Sha, H., Yang, L., Liu, M., Liu, F., Kersten, S. and Qi, L. 2013. Adipocyte XBP1s promotes adiponectin multimerization and systemic glucose homeostasis. Diabetes. Nov 15. Epub ahead of print. PMID: 24241534 [Pubmed]

• Iwata, T.N., Cowley, T.J., Sloma, M., Ji, Y., Kim, H., Qi, L., and Lee, S.S. 2013. The Transcriptional Co-Regulator HCF-1 Is Required for INS-1 beta-cell Glucose-Stimulated Insulin Secretion. PLoS One 8:e78841.[Pubmed]

• Yang L., Sha H., Davisson R.L., Qi L. Phenformin activates unfolded protein response in an AMP-activated protein kinase (AMPK)-dependent manner. J Biol Chem. 2013 Apr 2. [Epub ahead of print]

• Duplan E., Giaime E., Viotti J., Sévalle J., Corti O., Brice A., Ariga H., Qi L., Checler F., da Costa C.A. ER-stress-associated functional link between Parkin and DJ-1 via a transcriptional cascade involving the tumor suppressor p53 and the spliced X-box binding protein XBP-1. J Cell Sci. 2013 Feb 27. [Epub ahead of print]

• Stanya K.J., Jacobi D., Liu S., Bhargava P., Dai L., Gangl M.R., Inouye K., Barlow J.L., Ji Y., Mizgerd J.P., Qi L., Shi H., McKenzie A.N., Lee C.H. 2013. Direct control of hepatic glucose production by interleukin-13 in mice. J. Clin. Invest. 123: 261-71 [Pubmed]

2012

• He, Y., Beatty, A., Han, X., Ji, Y., Ma, X., Adelstein, R., Yates, J.R., Kemphues, K., and Qi, L. 2012. Non-muscle myosin IIB links cytoskeleton to IRE1a signaling during ER stress. Dev Cell.  Dec 10. [Pubmed]

• Yang, Z., Wang, X., He, Y., Qi, L., Yu, L., Xue, B., Shi, H. 2012. The full capacity of AICAR to reduce obesity-induced inflammation and insulin resistance requires Myeloid Sirt1. PLoS One. 7 (11): e49935 [Pubmed]

• Ji, Y., Sun, S., Xia, S., Yang, L., Li, X., and Qi, L. 2012. Short-Term High-fat-Diet Challenge Promotes Alternative Macrophage Polarization in Adipose Tissue via Natural Killer T Cells and Interleukine-4. J. Biol. Chem. May 29. [Epub ahead of print]. [Pubmed]

• Sun, S. et al. and Qi, L. The ATP-P2X7 Signaling Axis Is Dispensable for Obesity-Associated Inflammasome Activation in Adipose Tissue. Diabetes. March 2012. [Pubmed]

• Ji, Y. et al. and Qi, L. Activation of natural killer T cells promotes M2 macrophage polarization in adipose tissue and improves systemic glucose tolerance via the IL-4/STAT6 signaling axis in obesity. J Biol Chem. March 2012. [Pubmed]

• Sun, S., Ji, Y., Kersten, S., Qi, L. Mechanisms of Inflammatory Responses in Obese Adipose Tissue. Annu. Rev. Nutr. March 2012. [Pubmed][F1000 Faculty]

2011

• Mao, T., Shao, M., Qiu, Y., Huang J., Zhang, Y., Song, B., Wang, Q., Jiang, L., Liu, Y., Han, J., Cao, P., Li, J., Gao, X., Rui, L., Qi, L., Li, W., and Liu, Y. (2011) PKA phosphorylation couples hepatic IRE1a to glucagon signaling in glucose metabolism. Proc. Natl. Acad. Sci. USA108: 15852-7. [Pubmed]

• Xue, Z. et al. (2011) A conserved structural determinant located at the interdomain region of mammalian IRE1{alpha}. J. Biol. Chem.286:30859-66. [Pubmed]

• Sha et al. (2011) Stressed out about obesity: IRE1α-XBP1 in metabolic disorders. Trends in Endocrinol Metab. 22:374-81. [Pubmed]

• Francisco, A.B., Singh, R., Sha, B., Qi, L., Lei, X., and Long, Q., 2010. Haploid insufficiency of suppressor enhancer Lin12 1-like (SEL1L) protein predisposes mice to high fat diet-induced hyperglycemia. J. Biol. Chem.86: 22275-82. [Pubmed]

• Xia, S., Sha, H.B., Yang, L., Ji, Y., Ostrand-Rosenberg, S. and Qi, L. (2011) Gr-1+ CD11b+ myeloid-derived suppressor cells suppress inflammation and promote insulin sensitivity in obesity.J. Biol. Chem.286: 23591-9. [Pubmed]

• Qi, L., Yang, L., and Chen, H. (2011) Detecting and Quantitating Physiological Endoplasmic Reticulum Stress in Mammals. Methods in Enzymology. 490: 137-146. [Pubmed]

2010

• He, Y., Sun, S., Sha, H., Liu, Z., Yang, L., Xue, Z., Chen, H. and Qi, L. (2010) Emerging Roles of XBP1, a sUPeR transcription factor. Gene Expression. 15: 13-25. [Pubmed]

• Lichtenstein, L., Mattijssen, F., de Wit, N.J., Georgiadi, A., Hooiveld, G.J., van der Meer, R., He., Y., Qi, L., Koster, A., Tamsma, J. T., Tan, N.S., Muller, M., and Kersten S. (2010) Angptl4 protects against severe pro-inflammatory effects of dietary saturated fat by inhibiting lipoprotein lipase-dependent uptake of fatty acids in mesenteric lymph node macrophages. Cell Metabolism. 12:580-592. [Pubmed]

• Yang, L., Xue, Z., He, Y., Sun, S., Chen, H. and Qi, L. (2010) A Phos-tag-based Approach Reveals the Extent of Physiological Endoplasmic Reticulum Stress. PLoS ONE. 5: e11621. [Pubmed]

• Zeng, L., Liu, Y.P.,Sha, H., Chen, H., Qi, L. and Smith, J.A. 2010. XBP-1 couples endoplasmic reticulum stress to augmented IFN-beta induction via a cis-acting enhancer in macrophages. J. Immunol. [Pubmed]

• Zmuda, E. J., Qi, L., Zhu, M., Mirmira, R., Montminy, M. and Hai, T. 2010. The role of ATF3, an adaptive-responsive gene, in high fat diet induced diabetes and pancreatic beta cell dysfunction. Mol. Endo. 24: 1423-33. [Pubmed]

• Liew, C.W., Bochenski, J., Kawamori, D., Hu, J., Leech, C.A., Wanic, K., Malecki, M., Warram, J., Qi, L., Krolewski, A.S., and Kulkarni, R.N. (2010) The tribbles protein interacts with ATF4 to regulate insulin exocytosis in human and mouse beta-cells. J. Clin. Invest. 120: 2876-2888. [Pubmed]

• Chen, H. and Qi, L. (2010) SUMO Modification Regulates Transcriptional Activity of XBP1. Biochem. J. 429: 95-102. [Pubmed]

• Francisco, A.B., Singh, R., Li., S., Vani, A.K., Yang, L., Munroe, R.J., Qi, L., Schimenti, J.C. and Long, Q., 2010. Deficiency of Sel1l in mice leads to systemic ER stress and embryonic lethality. J. Biol. Chem. 285: 13694-13703. [Pubmed]

2009

• Sha, H.B.*, He, Y.*, Chen, H., Wang, C., Zhang, X., Zenno, A., Shi, H., Yang, X., Zhang, X. and Qi, L. (2009) The IRE1a-XBP1 pathway of the unfolded protein response is required for adipogenesis. Cell Metabolism. 9: 556-564 (*, contribute equally) [PDF][1000 Faculty]

1997-2007 (Graduate and Postdoctoral Training)

• Qi, L.*, Saberi, M.*, Zmuda, E., Wang, Y., Altarejos, J., Zhang, X., Dentin, R., Hedrick, S., Bandyopadhyay, G., Hai, T., Olefsky, J. and Montminy, M. (2009). Adipocyte CREB promotes insulin resistance in obesity. Cell Metabolism. 9, 277-286 (*, contribute equally) [PDF]

• Qi, L.*, Heredia, J.*, Altarejos, J.Y., Screaton, R., Goebel, N., Niessen, S., MacLeod, I.X., Liew, C.W., Kulkarni, R., Bain, J., Nelson, M., Evans, R.M., Yates, J., and Montminy, M. 2006. TRB3 links the E3 ubiquitin ligase COP1 to lipid metabolism. Science. 312: 1763-6 (*, contribute equally) [PDF]

• Koo, S.H.*, Flechner, L.*, Qi, L., Zhang, X., Screaton, R.A., Jeffries, S., Hedrick, S., Xu, W., Boussouar, F., Brindle, P., Takemori, H., and Montminy, M. 2005. The CREB coactivator TORC2 is a key regulator of fasting glucose metabolism. Nature. 437: 1109-15 (*, contribute equally) [PDF]

• Qi, L., Strong, M.A., Karim, B.O., Huso, D.L., and Greider, C.W. 2005. Telomere fusion to chromosome breaks reduces oncogenic translocations and tumor formation. Nature Cell Biology. 7: 706-11. [PDF]

• Qi, L., Strong, M.A., Karim, B.O., Armanios, M., Huso, D.L., and Greider, C.W. 2003. Short telomeres and ataxia-telangiectasia mutated deficiency cooperatively increase telomere dysfunction and suppress tumorigenesis.Cancer Research. 63: 8188-96. [PDF]

• Dolan, B.P., Phelan, T.P., Ilkovitch, D., Qi, L., Wade, W.F., Laufer, T.M., and Ostrand-Rosenberg, S. 2004. Invariant chain and the MHC class II cytoplasmic domains regulate localization of MHC class II molecules to lipid rafts in tumor cell-based vaccines. Journal of Immunology. 172: 907-14. [PDF]

• Qi, L. and Ostrand-Rosenberg, S. 2001. H2-O inhibits presentation of bacterial superantigens, but not endogenous self-antigens. Journal of Immunology. 167: 1371-8. [PDF]

• Qi, L. and Ostrand-Rosenberg, S. 2000. MHC Class II presentation of endogenous tumor antigen by cellular vaccines depends on the endocytic pathway but not H2-M. Traffic. 1: 152–160. [PDF]

• Qi, L., Rojas, J., Ostrand-Rosenberg, S. 2000. Tumor cells present MHC class II-restricted nuclear and mitochondrial antigens and are the predominant antigen presenting cells in vivo. Journal of Immunology. 165: 5451-5461. [PDF]